Nutritional Supplements

Agaricus Blazei Murill Mushroom (ABM)

Agaricus originates from Piedade, which is located in the suburbs of Sao Paulo, Brazil. The climatic conditions in Piedade include temperatures that soar to 35-38 0C during the day and dip to between 20-25 C at night, with the humidity that averages 80%. The place also experiences regular squall toward evening. Agaricus Blazei Murill Mushroom (ABM) thrives only under these conditions, suggesting that its survival is significantly affected by these external conditions.

Around the same time, ABM Mushroom was introduced to Japan. Dr. Shoji Shibata, who at the time was a professor in the harmacological Department of Tokyo University, and Dr. Tetuo Ikegawa of the National Cancer Center, jointly I researched the pharmacological effects of 4 Agaricus. The research results were released at the general convention of the Japan Pharmacological Association and the Japan Cancer Association. The experience with mice verified that the polysaccharide beta-D-glucan contained in 4 Agaricus significantly activated the immune system.

The polysaccharide contained in Agaricus Blazei Murill vitalizes production of interferon and interleukin in small animals (guinea pigs). This effect indirectly functions to destroy or prevent the proliferation of cancer cells. This refers to a cytokine inducing effect. Moreover, the experiments conducted by the researchers named above proved that this effect can also prevent viruses and other external factors from entering the tissue.

Clinical results obtained in collaboration with university researchers and hospital since the report on the anti cancer effect of Agaricus Blazei Murril (ABM Mushroom) was released at the general convention of the Japan Cancer Association in 1980 proved that although many fungi polysaccharide only effect solid cancer and polysaccharide of Agaricus Blazei Murril is effective against Ehrlich’s ascites carcinoma sigmoid colonic cancer, ovarian cancer, breast cancer, lung cancer, and liver cancer as well as against solid cancer.

The results of the experiments suggest that it also activates metabolism by revitalizing normal biological tissue. Digestive enzymes such as amylase trypsin martase and the protease contained in fungus also enhances digestion. Furthermore, tyrosinase, an enzyme which oxidizes tyrosine and produces melanin, has a hypotensive effect.

Living organisms are equipped with immunity system which expels pathogens, toxic chemicals and tumorous cells generated through mutation. When tumorous cells attach to form a simple protein lump, it is Decomposed by microorganisms such as bacteria. Thanks to this function, which is called immunity, bodies can maintain their health by fighting off harmful microorganisms, stopping them from entering tissue or
discharging them from tissue.

The human immune system is comprised of more that 130 subsets of white blood cells. About 15% of them are called Natural Killer (NK) cells, These provide the first line of defense for dealing with any form of
invasion to the body. Each cell contains several small granules which act as ‘ammunition.’ When an NI( cell recognizes a cancer cell, for instance, it attaches itself to the cells outer membrane and inject these granules directly into the interior of the cell.

More specifically, natural killer cells or NK cells play a critical role neutralizing outside organisms such as viruses and bacteria that enter the body. Through a process called phagocytosis, the NK cells “kiss” and
engulf foreign agents and release toxic chemicals that destroy them.

In cancer patients, the NK cells and cancer cells constantly baffle one another. The NK cells attempt to destroy cancer cells while at the same time cancer cells try to neutralize NK cells before they can harm them. If the NK cells are weak or if there are not enough NK cells in the body, the cancer spreads through- out the body resulting in death. Several factors contribute to this weakening of the immune system: most notably stress, age, pollution, and smoking

When their immune systems work properly, humans remain healthy. However, the immune systems in many people are weakened by stress, poor eating habits and pollution, such as air pollution. These people can suffer from a number of diseases.

It is widely believed that cancer is caused by a decline in the immune system caused by aging and other factors. It is also known that atopic dermatitis asthma, pollinosis and rheumatism result from an excessive immuno reaction. The AIDS virus destroys immune cells and triggers diseases.

Agaricus Blazei Murill, which is enjoying growing attention, contains a large amount of polysaccharide, which is believed to enhance immunity. It does not only bolster immunity but reduces excessive immuno reactions to maintain a balance. Of all fungi, ABM Mushroom is particularly rich in polysaccharide, and has shown particularly strong results in treating and preventing cancer. We believe that Agaricus Blazei Murill is the ideal food for the people of today, who are exposed to a difficult living environment.

Mizuno, T., Hagiwara, T., Nakamura, T., Ito, H. Shimura, K. Suuuya, T., Asakura, A, 1990. Antituxnor activity and some prupcrties of water-insoluble hmtro-glyc.ns from “Himaiuatsutako,” the fruiting body of
Agaricus blnzei Murill, Agricultural & Biological Chemistry 54. Tokyo. pp. 2897-2905.

Ito, H., K. Shimura, H. Itoh, M. Kawade, 1997. “Autitumor effects of a new polysacobaride-pratem complex (ATOM) prepared from Agai-icus blazei (Jwadc strain 101) “Himematsutake” and its mechanisms iii tumor-bearing mice” Anticancer Research Jan-Feb 1 7( 1A): 277-84.

Itoh, H., H, Ito, H. Amino, and H. Nod., 1994. “Inhibitory action of a (l-->6)beta-D-glucan-protein
complex (P111-2-b) isolated from Agaricns blazci MurilI (“Hiinematautske”) on Moth A fibrosarcoma- bearing mice and its antitumor mechanism” Japanese Journal of Pharmacology Oct; 662): 265-7 1.

Kawagishi, H., A. Nomura, T. Yunien, T. Mizuno~ I. Hagwara and T. Nakamura, 1988. “Isolation and properties of a lectin from the fruiting bodies of Agaricus blazei” Carbohydrate Research Nov 15: 183(1): 150-4.

Kawagishi, H., R. lnagaki, T. Kanao, T. Mizuno, lC~ Shinmra, H. Ito, T. Hagiwara, and T. Nakamura, 1989. “Fractionation and aniitumor activity of the water insoluble residue of Agaricua blazei fruiting bodies Carbohydrate Research Mar. 15; 186(2): 267-73.

Mizuno, T, Hagiwara, T., Nakamura, 1., Ito, H, Shiniurs, K. Sumiya, T., Aaakura, A. 1990. “Antitumor activity and some properties of water-soluble polysaccbarides from ‘Himematsutnke,’ the fruiting body of Agancus blazei Murrifl” Agricultural & Biological Chemistry 54. Tokyo. 2889-2896.

Osakl, Y., T. Kato, K. Yamamto, 1. Okubo, T. Mlyankl, 1994. “Antlmutagenlc and bactericidal
substances In the fruit body of a Basldlomycete Agarlcus blazel” Journal of the Pharmaceutical
Society of Japan May; 114(5): 342.50

Mizuno, T, H. Ito, K, Shirnura, T. Hagiwara & T, Nakamura, 1989. “Preparation method of antitwnor neutral polysacchsrides from Himematsutake” Japan Kokai Tokkyo Koho (A), ShoG4-67 195, March 13, 56$568.

Mizuno, T, H. Ito, K. Shmtura, T. Hagiwara & T. Nakamura, 1989. “PreparatIon method of antitunior acidic glycanz from Himematcutake” Japan Kokai Tokkyo Kobo (A), Sho64-67 194, Match 13, 561-564.

ABM Mushroom Extract ( Agaricus Blazei Murill) 90 V-Caps 400 mg. Price $31.95

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